Controlled drug releasing of doxorubicin loaded magnetic nanoliposome using NIR irradiation

The effective delivery of therapeutic agent to target tissue is a central challenge in drug delivery. Therefore, externally stimuli controlled drug release has emerged as a promising method to localized delivery. In addition, the design of a suitable drug loaded nanocarrier to target lesion and response to a certain stimulus is also a main issue. In this study, we fabricate superparamagnetic iron oxide (SPIO) and doxorubicin (DOX) loaded magnetic nanoliposomes (MNL) as a thermal sensitive drug loaded nanocarrier. Moreover, near-infer red (NIR) light, as a non-invasive and remote control approach, is introduced to control release of the entrapped DOX. Based on the DOX releasing rate results, an irreversible release under NIR irradiation is proposed. In addition, a tumor cell killing effect of MNL combined with NIR light irradiation is evaluated. As a result, we achieve a significantly enhanced tumor cell killing effect. Therefore, we expect that an enhanced localized drug accumulation and an anti-tumor therapy can be achieved through NIR irradiation.