Comparison of diffuse optical tomography of human breast with whole-body and breast-only positron emission tomography

Soren D. Konecky; Regine Choe; Alper Corlu; Kijoon Lee; Rony Wiener; Shyam M. Srinivas; Janet R. Saffer; Richard Freifelder; Joel S. Karp; Nassim Hajjioui; Fred Azar; Arjun G. Yodh

doi:10.1118/1.2826560

Comparison of diffuse optical tomography of human breast with whole-body and breast-only positron emission tomography

Soren D. Konecky, Regine Choe, Alper Corlu, Kijoon Lee, Rony Wiener, Shyam M. Srinivas, Janet R. Saffer, Richard Freifelder, Joel S. Karp, Nassim Hajjioui, Fred Azar, Arjun G. Yodh

Department of Electrical Engineering and Computer Science

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

We acquire and compare three-dimensional tomographic breast images of three females with suspicious masses using diffuse optical tomography (DOT) and positron emission tomography (PET). Co-registration of DOT and PET images was facilitated by a mutual information maximization algorithm. We also compared DOT and whole-body PET images of 14 patients with breast abnormalities. Positive correlations were found between total hemoglobin concentration and tissue scattering measured by DOT, and fluorodeoxyglucose (F18 -FDG) uptake. In light of these observations, we suggest potential benefits of combining both PET and DOT for characterization of breast lesions.

Original language	English
Pages (from-to)	446-455
Number of pages	10
Journal	Medical Physics
Volume	35
Issue number	2
DOIs	https://doi.org/10.1118/1.2826560
State	Published - 2008

Bibliographical note

Funding Information:
The authors thank J. P. Culver for his initial work on the optical instrumentation, M. Grosicka-Koptyra for patient recruitment and measurement, and M. D. Schnall, M. A. Rosen, B. J. Czerniecki, and J. C. Tchou for patient recruitment. This research was supported by Grant Nos. NIH R01-CA75124, NIH R01 EB-002109, NTROI 1U54CA105480, NIH P01-CA85424, and DOE DE-FG02-88ER60642.

Keywords

Breast cancer
Breast imaging
Diffuse optical tomography
F fluorodeoxyglucose
Hypoxia
Near-infrared imaging
Positron emission tomography
Tumor metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1118/1.2826560

Cite this

@article{63088b9e151643be9fd608d7451de070,

title = "Comparison of diffuse optical tomography of human breast with whole-body and breast-only positron emission tomography",

abstract = "We acquire and compare three-dimensional tomographic breast images of three females with suspicious masses using diffuse optical tomography (DOT) and positron emission tomography (PET). Co-registration of DOT and PET images was facilitated by a mutual information maximization algorithm. We also compared DOT and whole-body PET images of 14 patients with breast abnormalities. Positive correlations were found between total hemoglobin concentration and tissue scattering measured by DOT, and fluorodeoxyglucose (F18 -FDG) uptake. In light of these observations, we suggest potential benefits of combining both PET and DOT for characterization of breast lesions.",

keywords = "Breast cancer, Breast imaging, Diffuse optical tomography, F fluorodeoxyglucose, Hypoxia, Near-infrared imaging, Positron emission tomography, Tumor metabolism",

author = "Konecky, \{Soren D.\} and Regine Choe and Alper Corlu and Kijoon Lee and Rony Wiener and Srinivas, \{Shyam M.\} and Saffer, \{Janet R.\} and Richard Freifelder and Karp, \{Joel S.\} and Nassim Hajjioui and Fred Azar and Yodh, \{Arjun G.\}",

note = "Funding Information: The authors thank J. P. Culver for his initial work on the optical instrumentation, M. Grosicka-Koptyra for patient recruitment and measurement, and M. D. Schnall, M. A. Rosen, B. J. Czerniecki, and J. C. Tchou for patient recruitment. This research was supported by Grant Nos. NIH R01-CA75124, NIH R01 EB-002109, NTROI 1U54CA105480, NIH P01-CA85424, and DOE DE-FG02-88ER60642. ",

year = "2008",

doi = "10.1118/1.2826560",

language = "English",

volume = "35",

pages = "446--455",

journal = "Medical Physics",

issn = "0094-2405",

publisher = "John Wiley and Sons Ltd",

number = "2",

}

TY - JOUR

T1 - Comparison of diffuse optical tomography of human breast with whole-body and breast-only positron emission tomography

AU - Konecky, Soren D.

AU - Choe, Regine

AU - Corlu, Alper

AU - Lee, Kijoon

AU - Wiener, Rony

AU - Srinivas, Shyam M.

AU - Saffer, Janet R.

AU - Freifelder, Richard

AU - Karp, Joel S.

AU - Hajjioui, Nassim

AU - Azar, Fred

AU - Yodh, Arjun G.

N1 - Funding Information: The authors thank J. P. Culver for his initial work on the optical instrumentation, M. Grosicka-Koptyra for patient recruitment and measurement, and M. D. Schnall, M. A. Rosen, B. J. Czerniecki, and J. C. Tchou for patient recruitment. This research was supported by Grant Nos. NIH R01-CA75124, NIH R01 EB-002109, NTROI 1U54CA105480, NIH P01-CA85424, and DOE DE-FG02-88ER60642.

PY - 2008

Y1 - 2008

N2 - We acquire and compare three-dimensional tomographic breast images of three females with suspicious masses using diffuse optical tomography (DOT) and positron emission tomography (PET). Co-registration of DOT and PET images was facilitated by a mutual information maximization algorithm. We also compared DOT and whole-body PET images of 14 patients with breast abnormalities. Positive correlations were found between total hemoglobin concentration and tissue scattering measured by DOT, and fluorodeoxyglucose (F18 -FDG) uptake. In light of these observations, we suggest potential benefits of combining both PET and DOT for characterization of breast lesions.

AB - We acquire and compare three-dimensional tomographic breast images of three females with suspicious masses using diffuse optical tomography (DOT) and positron emission tomography (PET). Co-registration of DOT and PET images was facilitated by a mutual information maximization algorithm. We also compared DOT and whole-body PET images of 14 patients with breast abnormalities. Positive correlations were found between total hemoglobin concentration and tissue scattering measured by DOT, and fluorodeoxyglucose (F18 -FDG) uptake. In light of these observations, we suggest potential benefits of combining both PET and DOT for characterization of breast lesions.

KW - Breast cancer

KW - Breast imaging

KW - Diffuse optical tomography

KW - F fluorodeoxyglucose

KW - Hypoxia

KW - Near-infrared imaging

KW - Positron emission tomography

KW - Tumor metabolism

UR - https://www.scopus.com/pages/publications/38849095393

U2 - 10.1118/1.2826560

DO - 10.1118/1.2826560

M3 - Article

C2 - 18383664

AN - SCOPUS:38849095393

SN - 0094-2405

VL - 35

SP - 446

EP - 455

JO - Medical Physics

JF - Medical Physics

IS - 2

ER -

Comparison of diffuse optical tomography of human breast with whole-body and breast-only positron emission tomography

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this