Colloidal inverse bicontinuous cubic membranes of block copolymers with tunable surface functional groups

Yunju La; Chiyoung Park; Tae Joo Shin; Sang Hoon Joo; Sebyung Kang; Kyoung Taek Kim

doi:10.1038/nchem.1946

Colloidal inverse bicontinuous cubic membranes of block copolymers with tunable surface functional groups

Yunju La, Chiyoung Park, Tae Joo Shin, Sang Hoon Joo, Sebyung Kang, Kyoung Taek Kim

Department of Energy and Science and Engineering

Research output: Contribution to journal › Article › peer-review

133 Scopus citations

Abstract

Analogous to the complex membranes found in cellular organelles, such as the endoplasmic reticulum, the inverse cubic mesophases of lipids and their colloidal forms (cubosomes) possess internal networks of water channels arranged in crystalline order, which provide a unique nanospace for membrane-protein crystallization and guest encapsulation. Polymeric analogues of cubosomes formed by the direct self-assembly of block copolymers in solution could provide new polymeric mesoporous materials with a three-dimensionally organized internal maze of large water channels. Here we report the self-assembly of amphiphilic dendritic-linear block copolymers into polymer cubosomes in aqueous solution. The presence of precisely defined bulky dendritic blocks drives the block copolymers to form spontaneously highly curved bilayers in aqueous solution. This results in the formation of colloidal inverse bicontinuous cubic mesophases. The internal networks of water channels provide a high surface area with tunable surface functional groups that can serve as anchoring points for large guests such as proteins and enzymes.

Original language	English
Pages (from-to)	534-541
Number of pages	8
Journal	Nature Chemistry
Volume	6
Issue number	6
DOIs	https://doi.org/10.1038/nchem.1946
State	Published - Jun 2014

Bibliographical note

Funding Information:
This research was supported by the National Research Foundation (NRF) of Korea (NRF-2013R1A1A013075) and Ulsan National Institute of Science and Technology (2012 Future Challenge Research Fund, 1.130014). C.P. acknowledges the NRF for a research fellowship (2013R1A1A2063049): S.H.J.and S.K. thank NRF for financial support (2013R1A1A2012960, ARC 2010-0028684). K.T.K also thanks KUCC for financial support (2V03280). We thank the Unist Central Research Facilities and the Unist-Olympus Biomed Imaging Center for microscopy facilities. We thank J. Y. Cheon and Y. J. Kang for the help with adsorption experiments and protein labelling. We also thank M. G. Jeong for the graphical illustrations.

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title = "Colloidal inverse bicontinuous cubic membranes of block copolymers with tunable surface functional groups",

abstract = "Analogous to the complex membranes found in cellular organelles, such as the endoplasmic reticulum, the inverse cubic mesophases of lipids and their colloidal forms (cubosomes) possess internal networks of water channels arranged in crystalline order, which provide a unique nanospace for membrane-protein crystallization and guest encapsulation. Polymeric analogues of cubosomes formed by the direct self-assembly of block copolymers in solution could provide new polymeric mesoporous materials with a three-dimensionally organized internal maze of large water channels. Here we report the self-assembly of amphiphilic dendritic-linear block copolymers into polymer cubosomes in aqueous solution. The presence of precisely defined bulky dendritic blocks drives the block copolymers to form spontaneously highly curved bilayers in aqueous solution. This results in the formation of colloidal inverse bicontinuous cubic mesophases. The internal networks of water channels provide a high surface area with tunable surface functional groups that can serve as anchoring points for large guests such as proteins and enzymes.",

author = "Yunju La and Chiyoung Park and Shin, \{Tae Joo\} and Joo, \{Sang Hoon\} and Sebyung Kang and Kim, \{Kyoung Taek\}",

note = "Funding Information: This research was supported by the National Research Foundation (NRF) of Korea (NRF-2013R1A1A013075) and Ulsan National Institute of Science and Technology (2012 Future Challenge Research Fund, 1.130014). C.P. acknowledges the NRF for a research fellowship (2013R1A1A2063049): S.H.J.and S.K. thank NRF for financial support (2013R1A1A2012960, ARC 2010-0028684). K.T.K also thanks KUCC for financial support (2V03280). We thank the Unist Central Research Facilities and the Unist-Olympus Biomed Imaging Center for microscopy facilities. We thank J. Y. Cheon and Y. J. Kang for the help with adsorption experiments and protein labelling. We also thank M. G. Jeong for the graphical illustrations.",

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Colloidal inverse bicontinuous cubic membranes of block copolymers with tunable surface functional groups

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