Biological sensors based on Brownian relaxation of magnetic nanoparticles

S. H. Chung; A. Hoffmann; S. D. Bader; C. Liu; B. Kay; L. Makowski; L. Chen

doi:10.1063/1.1801687

Biological sensors based on Brownian relaxation of magnetic nanoparticles

S. H. Chung
, A. Hoffmann
, S. D. Bader
, C. Liu
, B. Kay
, L. Makowski
, L. Chen

Division of Nanotechnology

Argonne National Laboratory

Research output: Contribution to journal › Article › peer-review

234 Scopus citations

Abstract

A biomagnetic sensor scheme based on Brownian relaxation of magnetic nanoparticles suspended in liquids was discussed. It was suggested that the characteristic time scale of the Brownian relaxation can be determined directly by ac susceptibility measurements as a function of frequency. It was observed that the peak in the imaginary part of the ac susceptibility shifts to lower frequencies upon binding the target molecules to the magnetic nanoparticles. The frequency shift was found to be consistent with an increase of the hydrodynamic radius corresponding to the size of the target molecule.

Original language	English
Pages (from-to)	2971-2973
Number of pages	3
Journal	Applied Physics Letters
Volume	85
Issue number	14
DOIs	https://doi.org/10.1063/1.1801687
State	Published - 4 Oct 2004

Bibliographical note

Funding Information:
The authors acknowledge stimulating discussions with J. Meersschaut. This work was supported by the U. S. Department of Energy, Basic Energy Sciences, under Contract No. W-31-109-ENG-38 and DARPA, under Contract No. 8C67400.

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10.1063/1.1801687

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abstract = "A biomagnetic sensor scheme based on Brownian relaxation of magnetic nanoparticles suspended in liquids was discussed. It was suggested that the characteristic time scale of the Brownian relaxation can be determined directly by ac susceptibility measurements as a function of frequency. It was observed that the peak in the imaginary part of the ac susceptibility shifts to lower frequencies upon binding the target molecules to the magnetic nanoparticles. The frequency shift was found to be consistent with an increase of the hydrodynamic radius corresponding to the size of the target molecule.",

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note = "Funding Information: The authors acknowledge stimulating discussions with J. Meersschaut. This work was supported by the U. S. Department of Energy, Basic Energy Sciences, under Contract No. W-31-109-ENG-38 and DARPA, under Contract No. 8C67400.",

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T1 - Biological sensors based on Brownian relaxation of magnetic nanoparticles

AU - Chung, S. H.

AU - Hoffmann, A.

AU - Bader, S. D.

AU - Liu, C.

AU - Kay, B.

AU - Makowski, L.

AU - Chen, L.

N1 - Funding Information: The authors acknowledge stimulating discussions with J. Meersschaut. This work was supported by the U. S. Department of Energy, Basic Energy Sciences, under Contract No. W-31-109-ENG-38 and DARPA, under Contract No. 8C67400.

PY - 2004/10/4

Y1 - 2004/10/4

N2 - A biomagnetic sensor scheme based on Brownian relaxation of magnetic nanoparticles suspended in liquids was discussed. It was suggested that the characteristic time scale of the Brownian relaxation can be determined directly by ac susceptibility measurements as a function of frequency. It was observed that the peak in the imaginary part of the ac susceptibility shifts to lower frequencies upon binding the target molecules to the magnetic nanoparticles. The frequency shift was found to be consistent with an increase of the hydrodynamic radius corresponding to the size of the target molecule.

AB - A biomagnetic sensor scheme based on Brownian relaxation of magnetic nanoparticles suspended in liquids was discussed. It was suggested that the characteristic time scale of the Brownian relaxation can be determined directly by ac susceptibility measurements as a function of frequency. It was observed that the peak in the imaginary part of the ac susceptibility shifts to lower frequencies upon binding the target molecules to the magnetic nanoparticles. The frequency shift was found to be consistent with an increase of the hydrodynamic radius corresponding to the size of the target molecule.

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DO - 10.1063/1.1801687

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VL - 85

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JO - Applied Physics Letters

JF - Applied Physics Letters

IS - 14

ER -

Biological sensors based on Brownian relaxation of magnetic nanoparticles

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