Biological sensing with magnetic nanoparticles using Brownian relaxation (invited)

S. H. Chung; A. Hoffmann; K. Guslienko; S. D. Bader; C. Liu; B. Kay; L. Makowski; L. Chen

doi:10.1063/1.1853694

Biological sensing with magnetic nanoparticles using Brownian relaxation (invited)

S. H. Chung, A. Hoffmann, K. Guslienko, S. D. Bader, C. Liu, B. Kay, L. Makowski, L. Chen

Division of Nanotechnology

Argonne National Laboratory

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

Abstract

Magnetic nanoparticles coated with biochemical ligands are enabling many biological and medical applications. In particular biomagnetic sensors have potential advantages of simplicity and rapidity. We demonstrate a substrate-free biomagnetic sensing approach using the magnetic ac susceptibility of ferromagnetic particles suspended in a liquid. The magnetic relaxation of these particles is mainly due to Brownian rotational diffusion, which can be modified by binding the particles to the intended target. This scheme has several advantages: (i) it requires only one binding event; (ii) there is an inherent check of integrity; and (iii) the signal contains additional information about the target size.

Original language	English
Article number	10R101
Journal	Journal of Applied Physics
Volume	97
Issue number	10
DOIs	https://doi.org/10.1063/1.1853694
State	Published - 15 May 2005

Bibliographical note

Funding Information:
This work was supported by the U. S. Department of Energy, Basic Energy Sciences-Materials Science, under Contract No. W-31-109-ENG-38 and DARPA, under Contract No. 8C67400.

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abstract = "Magnetic nanoparticles coated with biochemical ligands are enabling many biological and medical applications. In particular biomagnetic sensors have potential advantages of simplicity and rapidity. We demonstrate a substrate-free biomagnetic sensing approach using the magnetic ac susceptibility of ferromagnetic particles suspended in a liquid. The magnetic relaxation of these particles is mainly due to Brownian rotational diffusion, which can be modified by binding the particles to the intended target. This scheme has several advantages: (i) it requires only one binding event; (ii) there is an inherent check of integrity; and (iii) the signal contains additional information about the target size.",

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AU - Chung, S. H.

AU - Hoffmann, A.

AU - Guslienko, K.

AU - Bader, S. D.

AU - Liu, C.

AU - Kay, B.

AU - Makowski, L.

AU - Chen, L.

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AB - Magnetic nanoparticles coated with biochemical ligands are enabling many biological and medical applications. In particular biomagnetic sensors have potential advantages of simplicity and rapidity. We demonstrate a substrate-free biomagnetic sensing approach using the magnetic ac susceptibility of ferromagnetic particles suspended in a liquid. The magnetic relaxation of these particles is mainly due to Brownian rotational diffusion, which can be modified by binding the particles to the intended target. This scheme has several advantages: (i) it requires only one binding event; (ii) there is an inherent check of integrity; and (iii) the signal contains additional information about the target size.

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Biological sensing with magnetic nanoparticles using Brownian relaxation (invited)

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