TY - GEN
T1 - Biodegradable polymer droplet for efficient drug delivery using flagellated bacteria
AU - Hong, Seok Jun
AU - Koo, Kyo In
AU - Lee, Sang Min
AU - Park, Ho Soo
AU - Yoo, Hyung Jung
AU - Kim, Joonhwuy
AU - Park, Sukho
AU - Park, Jongoh
AU - Cho, Dong Il
PY - 2010
Y1 - 2010
N2 - This paper presents a biodegradable polymer droplet for efficient drug delivery using flagellated bacteria. The biodegradability and the localized delivery are the most important features for determining the efficiency of drug delivery. The proposed droplet is made of poly (DL-lactic-co-glycolic acid) for the biodegradability. It is fabricated using a microfluidic device which has a Y-junction microchannel. The fabricated biodegradable droplet has diameter in the range between 20 μm and 30 μm. Then flagellated bacteria, Serratia marcescens, are attached to these droplets for a localized drug delivery. The Serratia marcescens has a chemotaxis to tumor cells, and thus can be used as an actuation source of self-seeking to the tumor site. This paper presents the proposed concept, droplet fabrication, bacteria attachment, and observed rotational motion of the drug delivery methodology. The experimentally achieved maximum angular velocity is 0.11 rad/sec.
AB - This paper presents a biodegradable polymer droplet for efficient drug delivery using flagellated bacteria. The biodegradability and the localized delivery are the most important features for determining the efficiency of drug delivery. The proposed droplet is made of poly (DL-lactic-co-glycolic acid) for the biodegradability. It is fabricated using a microfluidic device which has a Y-junction microchannel. The fabricated biodegradable droplet has diameter in the range between 20 μm and 30 μm. Then flagellated bacteria, Serratia marcescens, are attached to these droplets for a localized drug delivery. The Serratia marcescens has a chemotaxis to tumor cells, and thus can be used as an actuation source of self-seeking to the tumor site. This paper presents the proposed concept, droplet fabrication, bacteria attachment, and observed rotational motion of the drug delivery methodology. The experimentally achieved maximum angular velocity is 0.11 rad/sec.
KW - Bacterial attachment
KW - Biodegradable polymer
KW - Droplet
KW - Drug delivery system
KW - Flagellated bacteria
UR - http://www.scopus.com/inward/record.url?scp=79951826754&partnerID=8YFLogxK
U2 - 10.1109/NANO.2010.5698031
DO - 10.1109/NANO.2010.5698031
M3 - Conference contribution
AN - SCOPUS:79951826754
SN - 9781424470334
T3 - 2010 10th IEEE Conference on Nanotechnology, NANO 2010
SP - 1072
EP - 1075
BT - 2010 10th IEEE Conference on Nanotechnology, NANO 2010
T2 - 2010 10th IEEE Conference on Nanotechnology, NANO 2010
Y2 - 17 August 2010 through 20 August 2010
ER -