Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879)

Santana A.L. Thomas; Anthony Sanchez; Younghoon Kee; Nerida G. Wilson; Bill J. Baker

doi:10.3390/md17090513

Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879)

Santana A.L. Thomas
, Anthony Sanchez
, Younghoon Kee
, Nerida G. Wilson
, Bill J. Baker

Department of New Biology

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

An Antarctic coral belonging to the order Pennatulacea, collected during the 2013 austral autumn by trawl from 662 to 944 m depth, has yielded three new briarane diterpenes, bathyptilone A-C (1–3) along with a trinorditerpene, enbepeanone A (4), which bears a new carbon skeleton. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy, mass spectrometry and confirmed by X-ray crystallography. The three compounds were screened in four cancer cell lines. Bathyptilone A displayed selective nanomolar cytotoxicity against the neurogenic mammalian cell line Ntera-2.

Original language	English
Article number	513
Journal	Marine Drugs
Volume	17
Issue number	9
DOIs	https://doi.org/10.3390/md17090513
State	Published - 1 Sep 2019

Bibliographical note

Publisher Copyright:
© 2019 by the authors.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Briarane diterpene
Cytotoxicity screening
Deep sea
Marine natural products
Pennatulacea

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10.3390/md17090513

Cite this

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title = "Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879)",

abstract = "An Antarctic coral belonging to the order Pennatulacea, collected during the 2013 austral autumn by trawl from 662 to 944 m depth, has yielded three new briarane diterpenes, bathyptilone A-C (1–3) along with a trinorditerpene, enbepeanone A (4), which bears a new carbon skeleton. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy, mass spectrometry and confirmed by X-ray crystallography. The three compounds were screened in four cancer cell lines. Bathyptilone A displayed selective nanomolar cytotoxicity against the neurogenic mammalian cell line Ntera-2.",

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author = "Thomas, \{Santana A.L.\} and Anthony Sanchez and Younghoon Kee and Wilson, \{Nerida G.\} and Baker, \{Bill J.\}",

note = "Publisher Copyright: {\textcopyright} 2019 by the authors.",

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month = sep,

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doi = "10.3390/md17090513",

language = "English",

volume = "17",

journal = "Marine Drugs",

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T1 - Bathyptilones

T2 - Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879)

AU - Thomas, Santana A.L.

AU - Sanchez, Anthony

AU - Kee, Younghoon

AU - Wilson, Nerida G.

AU - Baker, Bill J.

PY - 2019/9/1

Y1 - 2019/9/1

N2 - An Antarctic coral belonging to the order Pennatulacea, collected during the 2013 austral autumn by trawl from 662 to 944 m depth, has yielded three new briarane diterpenes, bathyptilone A-C (1–3) along with a trinorditerpene, enbepeanone A (4), which bears a new carbon skeleton. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy, mass spectrometry and confirmed by X-ray crystallography. The three compounds were screened in four cancer cell lines. Bathyptilone A displayed selective nanomolar cytotoxicity against the neurogenic mammalian cell line Ntera-2.

AB - An Antarctic coral belonging to the order Pennatulacea, collected during the 2013 austral autumn by trawl from 662 to 944 m depth, has yielded three new briarane diterpenes, bathyptilone A-C (1–3) along with a trinorditerpene, enbepeanone A (4), which bears a new carbon skeleton. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy, mass spectrometry and confirmed by X-ray crystallography. The three compounds were screened in four cancer cell lines. Bathyptilone A displayed selective nanomolar cytotoxicity against the neurogenic mammalian cell line Ntera-2.

KW - Briarane diterpene

KW - Cytotoxicity screening

KW - Deep sea

KW - Marine natural products

KW - Pennatulacea

UR - https://www.scopus.com/pages/publications/85071735593

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DO - 10.3390/md17090513

M3 - Article

C2 - 31480497

AN - SCOPUS:85071735593

SN - 1660-3397

VL - 17

JO - Marine Drugs

JF - Marine Drugs

IS - 9

M1 - 513

ER -

Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879)

Abstract

Bibliographical note

UN SDGs

Keywords

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