Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879)

Santana A.L. Thomas; Anthony Sanchez; Younghoon Kee; Nerida G. Wilson; Bill J. Baker

doi:10.3390/md17090513

Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879)

Santana A.L. Thomas, Anthony Sanchez, Younghoon Kee, Nerida G. Wilson, Bill J. Baker

Department of New Biology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

An Antarctic coral belonging to the order Pennatulacea, collected during the 2013 austral autumn by trawl from 662 to 944 m depth, has yielded three new briarane diterpenes, bathyptilone A-C (1–3) along with a trinorditerpene, enbepeanone A (4), which bears a new carbon skeleton. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy, mass spectrometry and confirmed by X-ray crystallography. The three compounds were screened in four cancer cell lines. Bathyptilone A displayed selective nanomolar cytotoxicity against the neurogenic mammalian cell line Ntera-2.

Original language	English
Article number	513
Journal	Marine Drugs
Volume	17
Issue number	9
DOIs	https://doi.org/10.3390/md17090513
State	Published - 1 Sep 2019

Bibliographical note

Publisher Copyright:
© 2019 by the authors.

Keywords

Briarane diterpene
Cytotoxicity screening
Deep sea
Marine natural products
Pennatulacea

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/md17090513

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title = "Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879)",

abstract = "An Antarctic coral belonging to the order Pennatulacea, collected during the 2013 austral autumn by trawl from 662 to 944 m depth, has yielded three new briarane diterpenes, bathyptilone A-C (1–3) along with a trinorditerpene, enbepeanone A (4), which bears a new carbon skeleton. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy, mass spectrometry and confirmed by X-ray crystallography. The three compounds were screened in four cancer cell lines. Bathyptilone A displayed selective nanomolar cytotoxicity against the neurogenic mammalian cell line Ntera-2.",

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Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879)

Abstract

Bibliographical note

Keywords

UN SDGs

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