Antimicrobial polyethyleneimine-silver nanoparticles in a stable colloidal dispersion

Hyun Ju Lee; Se Guen Lee; Eun Jung Oh; Ho Yun Chung; Sang Ik Han; Eun Jung Kim; Song Yi Seo; Han Do Ghim; Jeong Hyun Yeum; Jin Hyun Choi

doi:10.1016/j.colsurfb.2011.07.041

Antimicrobial polyethyleneimine-silver nanoparticles in a stable colloidal dispersion

Hyun Ju Lee
, Se Guen Lee
, Eun Jung Oh
, Ho Yun Chung
, Sang Ik Han
, Eun Jung Kim
, Song Yi Seo
, Han Do Ghim
, Jeong Hyun Yeum
, Jin Hyun Choi

Division of Biotechnology

Research output: Contribution to journal › Article › peer-review

102 Scopus citations

Abstract

Excellent colloidal stability and antimicrobial activity are important parameters for silver nanoparticles (AgNPs) in a range of biomedical applications. In this study, polyethyleneimine (PEI)-capped silver nanoparticles (PEI-AgNPs) were synthesized in the presence of sodium borohydride (NaBH ₄) and PEI at room temperature. The PEI-AgNPs had a positive zeta potential of approximately +49mV, and formed a stable nanocolloid against agglomeration due to electrostatic repulsion. The particle size and hydrodynamic cluster size showed significant correlations with the amount of PEI and NaBH ₄. PEI-AgNPs and even PEI showed excellent antimicrobial activity against Staphylococus aureus and Klebsiella pneumoniae. The cytotoxic effects of PEI and PEI-AgNPs were confirmed by an evaluation of the cell viability. The results suggest that the amount of PEI should be minimized to the level that maintains the stability of PEI-AgNPs in a colloidal dispersion.

Original language	English
Pages (from-to)	505-511
Number of pages	7
Journal	Colloids and Surfaces B: Biointerfaces
Volume	88
Issue number	1
DOIs	https://doi.org/10.1016/j.colsurfb.2011.07.041
State	Published - 1 Nov 2011

Bibliographical note

Funding Information:
This study was supported by grants from the Agenda Program ( PJ0073852010 ) of the National Institute of Crop Science , Rural Development Administration (RDA), Republic of Korea.

Keywords

Antimicrobial activity
Cytotoxicity
Polyethyleneimine
Silver nanoparticles
Sodium borohydride
Stability

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10.1016/j.colsurfb.2011.07.041

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title = "Antimicrobial polyethyleneimine-silver nanoparticles in a stable colloidal dispersion",

abstract = "Excellent colloidal stability and antimicrobial activity are important parameters for silver nanoparticles (AgNPs) in a range of biomedical applications. In this study, polyethyleneimine (PEI)-capped silver nanoparticles (PEI-AgNPs) were synthesized in the presence of sodium borohydride (NaBH 4) and PEI at room temperature. The PEI-AgNPs had a positive zeta potential of approximately +49mV, and formed a stable nanocolloid against agglomeration due to electrostatic repulsion. The particle size and hydrodynamic cluster size showed significant correlations with the amount of PEI and NaBH 4. PEI-AgNPs and even PEI showed excellent antimicrobial activity against Staphylococus aureus and Klebsiella pneumoniae. The cytotoxic effects of PEI and PEI-AgNPs were confirmed by an evaluation of the cell viability. The results suggest that the amount of PEI should be minimized to the level that maintains the stability of PEI-AgNPs in a colloidal dispersion.",

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note = "Funding Information: This study was supported by grants from the Agenda Program ( PJ0073852010 ) of the National Institute of Crop Science , Rural Development Administration (RDA), Republic of Korea.",

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AU - Lee, Hyun Ju

AU - Lee, Se Guen

AU - Oh, Eun Jung

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AU - Han, Sang Ik

AU - Kim, Eun Jung

AU - Seo, Song Yi

AU - Ghim, Han Do

AU - Yeum, Jeong Hyun

AU - Choi, Jin Hyun

N1 - Funding Information: This study was supported by grants from the Agenda Program ( PJ0073852010 ) of the National Institute of Crop Science , Rural Development Administration (RDA), Republic of Korea.

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N2 - Excellent colloidal stability and antimicrobial activity are important parameters for silver nanoparticles (AgNPs) in a range of biomedical applications. In this study, polyethyleneimine (PEI)-capped silver nanoparticles (PEI-AgNPs) were synthesized in the presence of sodium borohydride (NaBH 4) and PEI at room temperature. The PEI-AgNPs had a positive zeta potential of approximately +49mV, and formed a stable nanocolloid against agglomeration due to electrostatic repulsion. The particle size and hydrodynamic cluster size showed significant correlations with the amount of PEI and NaBH 4. PEI-AgNPs and even PEI showed excellent antimicrobial activity against Staphylococus aureus and Klebsiella pneumoniae. The cytotoxic effects of PEI and PEI-AgNPs were confirmed by an evaluation of the cell viability. The results suggest that the amount of PEI should be minimized to the level that maintains the stability of PEI-AgNPs in a colloidal dispersion.

AB - Excellent colloidal stability and antimicrobial activity are important parameters for silver nanoparticles (AgNPs) in a range of biomedical applications. In this study, polyethyleneimine (PEI)-capped silver nanoparticles (PEI-AgNPs) were synthesized in the presence of sodium borohydride (NaBH 4) and PEI at room temperature. The PEI-AgNPs had a positive zeta potential of approximately +49mV, and formed a stable nanocolloid against agglomeration due to electrostatic repulsion. The particle size and hydrodynamic cluster size showed significant correlations with the amount of PEI and NaBH 4. PEI-AgNPs and even PEI showed excellent antimicrobial activity against Staphylococus aureus and Klebsiella pneumoniae. The cytotoxic effects of PEI and PEI-AgNPs were confirmed by an evaluation of the cell viability. The results suggest that the amount of PEI should be minimized to the level that maintains the stability of PEI-AgNPs in a colloidal dispersion.

KW - Antimicrobial activity

KW - Cytotoxicity

KW - Polyethyleneimine

KW - Silver nanoparticles

KW - Sodium borohydride

KW - Stability

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Antimicrobial polyethyleneimine-silver nanoparticles in a stable colloidal dispersion

Abstract

Bibliographical note

Keywords

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