A three-dimensional model of fluid-structural interactions for quantifying the contractile force for cardiomyocytes on hybrid biopolymer microcantilever

Jungyul Park; Suk Kyu Ryu; Jinseok Kim; Junghun Cha; Jeongeun Baek; Sukho Park; Byungkyu Kim; Sang Ho Lee

doi:10.1016/j.jbiomech.2007.03.026

A three-dimensional model of fluid-structural interactions for quantifying the contractile force for cardiomyocytes on hybrid biopolymer microcantilever

Jungyul Park, Suk Kyu Ryu, Jinseok Kim, Junghun Cha, Jeongeun Baek, Sukho Park, Byungkyu Kim, Sang Ho Lee

Department of Robotics and Mechatronics Engineering

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Quantitatively analysis of the contractility of cardiomyocytes is important for understanding the mechanism of heart failure as well as the molecular alterations in diseased heart cells. This paper presents a realistic computational model, which considers the three-dimensional fluid-structural interactions (FSI), to quantify the contractile force of cardiomyocytes on hybrid biopolymer microcantilevers. Prior to this study, only static modeling of the microscale cellular force has been reported. This study modeled the dynamics of cardiomyocytes on microcantilevers in a medium using the FSI. This realistic model was compared with static finite element modeling (FEM) analysis and the Stoney's equation-based analytical solution, and was validated by the deflections of the microcantilevers in the experimental results. Using harmonic response analysis in FSI modeling, the motion of a hybrid biopolymer microcantilever in the medium was identified as a second-order system and the influence of the dynamics of cardiomyocytes could be evaluated quantitatively.

Original language	English
Pages (from-to)	2823-2830
Number of pages	8
Journal	Journal of Biomechanics
Volume	40
Issue number	13
DOIs	https://doi.org/10.1016/j.jbiomech.2007.03.026
State	Published - 2007

Bibliographical note

Funding Information:
This research was supported by the Intelligent Microsystems Center, which funds many of the 21st Century's Frontier R&D Projects sponsored by the Korea Ministry of Commerce, Industry and Energy and by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD) (KRF-2006-214-D0013).

Keywords

Cardiomyocyte
Contractile force
FEM
Fluid-structure interactions
Microcantilever

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10.1016/j.jbiomech.2007.03.026

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title = "A three-dimensional model of fluid-structural interactions for quantifying the contractile force for cardiomyocytes on hybrid biopolymer microcantilever",

abstract = "Quantitatively analysis of the contractility of cardiomyocytes is important for understanding the mechanism of heart failure as well as the molecular alterations in diseased heart cells. This paper presents a realistic computational model, which considers the three-dimensional fluid-structural interactions (FSI), to quantify the contractile force of cardiomyocytes on hybrid biopolymer microcantilevers. Prior to this study, only static modeling of the microscale cellular force has been reported. This study modeled the dynamics of cardiomyocytes on microcantilevers in a medium using the FSI. This realistic model was compared with static finite element modeling (FEM) analysis and the Stoney's equation-based analytical solution, and was validated by the deflections of the microcantilevers in the experimental results. Using harmonic response analysis in FSI modeling, the motion of a hybrid biopolymer microcantilever in the medium was identified as a second-order system and the influence of the dynamics of cardiomyocytes could be evaluated quantitatively.",

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author = "Jungyul Park and Ryu, {Suk Kyu} and Jinseok Kim and Junghun Cha and Jeongeun Baek and Sukho Park and Byungkyu Kim and Lee, {Sang Ho}",

note = "Funding Information: This research was supported by the Intelligent Microsystems Center, which funds many of the 21st Century's Frontier R&D Projects sponsored by the Korea Ministry of Commerce, Industry and Energy and by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD) (KRF-2006-214-D0013).",

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AU - Cha, Junghun

AU - Baek, Jeongeun

AU - Park, Sukho

AU - Kim, Byungkyu

AU - Lee, Sang Ho

N1 - Funding Information: This research was supported by the Intelligent Microsystems Center, which funds many of the 21st Century's Frontier R&D Projects sponsored by the Korea Ministry of Commerce, Industry and Energy and by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD) (KRF-2006-214-D0013).

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N2 - Quantitatively analysis of the contractility of cardiomyocytes is important for understanding the mechanism of heart failure as well as the molecular alterations in diseased heart cells. This paper presents a realistic computational model, which considers the three-dimensional fluid-structural interactions (FSI), to quantify the contractile force of cardiomyocytes on hybrid biopolymer microcantilevers. Prior to this study, only static modeling of the microscale cellular force has been reported. This study modeled the dynamics of cardiomyocytes on microcantilevers in a medium using the FSI. This realistic model was compared with static finite element modeling (FEM) analysis and the Stoney's equation-based analytical solution, and was validated by the deflections of the microcantilevers in the experimental results. Using harmonic response analysis in FSI modeling, the motion of a hybrid biopolymer microcantilever in the medium was identified as a second-order system and the influence of the dynamics of cardiomyocytes could be evaluated quantitatively.

AB - Quantitatively analysis of the contractility of cardiomyocytes is important for understanding the mechanism of heart failure as well as the molecular alterations in diseased heart cells. This paper presents a realistic computational model, which considers the three-dimensional fluid-structural interactions (FSI), to quantify the contractile force of cardiomyocytes on hybrid biopolymer microcantilevers. Prior to this study, only static modeling of the microscale cellular force has been reported. This study modeled the dynamics of cardiomyocytes on microcantilevers in a medium using the FSI. This realistic model was compared with static finite element modeling (FEM) analysis and the Stoney's equation-based analytical solution, and was validated by the deflections of the microcantilevers in the experimental results. Using harmonic response analysis in FSI modeling, the motion of a hybrid biopolymer microcantilever in the medium was identified as a second-order system and the influence of the dynamics of cardiomyocytes could be evaluated quantitatively.

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A three-dimensional model of fluid-structural interactions for quantifying the contractile force for cardiomyocytes on hybrid biopolymer microcantilever

Abstract

Bibliographical note

Keywords

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