TY - JOUR
T1 - A soft, wearable microfluidic device for the capture, storage, and colorimetric sensing of sweat
AU - Koh, Ahyeon
AU - Kang, Daeshik
AU - Xue, Yeguang
AU - Lee, Seungmin
AU - Pielak, Rafal M.
AU - Kim, Jeonghyun
AU - Hwang, Taehwan
AU - Min, Seunghwan
AU - Banks, Anthony
AU - Bastien, Philippe
AU - Manco, Megan C.
AU - Wang, Liang
AU - Ammann, Kaitlyn R.
AU - Jang, Kyung In
AU - Won, Phillip
AU - Han, Seungyong
AU - Ghaffari, Roozbeh
AU - Paik, Ungyu
AU - Slepian, Marvin J.
AU - Balooch, Guive
AU - Huang, Yonggang
AU - Rogers, John A.
N1 - Publisher Copyright:
© The Authors, some rights reserved;.
PY - 2016/11/23
Y1 - 2016/11/23
N2 - Capabilities in health monitoring enabled by capture and quantitative chemical analysis of sweat could complement, or potentially obviate the need for, approaches based on sporadic assessment of blood samples. Established sweat monitoring technologies use simple fabric swatches and are limited to basic analysis in controlled laboratory or hospital settings. We present a collection of materials and device designs for soft, flexible, and stretchable microfluidic systems, including embodiments that integrate wireless communication electronics, which can intimately and robustly bond to the surface of the skin without chemical and mechanical irritation. This integration defines access points for a small set of sweat glands such that perspiration spontaneously initiates routing of sweat through a microfluidic network and set of reservoirs. Embedded chemical analyses respond in colorimetric fashion to markers such as chloride and hydronium ions, glucose, and lactate. Wireless interfaces to digital image capture hardware serve as a means for quantitation. Human studies demonstrated the functionality of this microfluidic device during fitness cycling in a controlled environment and during long-distance bicycle racing in arid, outdoor conditions. The results include quantitative values for sweat rate, total sweat loss, pH, and concentration of chloride and lactate.2016
AB - Capabilities in health monitoring enabled by capture and quantitative chemical analysis of sweat could complement, or potentially obviate the need for, approaches based on sporadic assessment of blood samples. Established sweat monitoring technologies use simple fabric swatches and are limited to basic analysis in controlled laboratory or hospital settings. We present a collection of materials and device designs for soft, flexible, and stretchable microfluidic systems, including embodiments that integrate wireless communication electronics, which can intimately and robustly bond to the surface of the skin without chemical and mechanical irritation. This integration defines access points for a small set of sweat glands such that perspiration spontaneously initiates routing of sweat through a microfluidic network and set of reservoirs. Embedded chemical analyses respond in colorimetric fashion to markers such as chloride and hydronium ions, glucose, and lactate. Wireless interfaces to digital image capture hardware serve as a means for quantitation. Human studies demonstrated the functionality of this microfluidic device during fitness cycling in a controlled environment and during long-distance bicycle racing in arid, outdoor conditions. The results include quantitative values for sweat rate, total sweat loss, pH, and concentration of chloride and lactate.2016
UR - http://www.scopus.com/inward/record.url?scp=84997771406&partnerID=8YFLogxK
U2 - 10.1126/scitranslmed.aaf2593
DO - 10.1126/scitranslmed.aaf2593
M3 - Article
C2 - 27881826
AN - SCOPUS:84997771406
SN - 1946-6234
VL - 8
JO - Science Translational Medicine
JF - Science Translational Medicine
IS - 366
M1 - 2593
ER -
