TY - JOUR
T1 - A soft-magnet-based drug-delivery module for active locomotive intestinal capsule endoscopy using an electromagnetic actuation system
AU - Le, Viet Ha
AU - Rodriguez, Hernando Leon
AU - Lee, Cheong
AU - Go, Gwangjun
AU - Zhen, Jin
AU - Nguyen, Van Du
AU - Choi, Hyunchul
AU - Ko, Seong Young
AU - Park, Jong Oh
AU - Park, Sukho
N1 - Publisher Copyright:
© 2016 Elsevier B.V. All rights reserved.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Nowadays, capsule endoscope (CE) technology is highly evaluated as a promising medical apparatus for minimally invasive diagnosis and therapy. Active locomotive capsule endoscopy (ALICE) using an electromagnetic actuation (EMA) system is one of the new state-of-the-art solutions that effectively increase the diagnostic ability of CE. Together with a locomotive CE, there are various requests for multifunctional modules that can deliver drugs or execute biopsy functions. This paper presents a drug delivery module for ALICE using EMA, where we adopt a soft magnet due to its special physical properties. The drug-delivery module consists of two ring-type soft magnets and a simple plastic hinge; it has a volume of 0.78 ml, which is approximately 26% the total volume of a conventional active CE. The drug-delivery module can be integrated with ALICE. First, the drug is encapsulated into the module by the attracting force between two axially magnetized soft-magnetic rings. Second, ALICE with the drug delivery module can be driven by a precisely controlled external magnetic field to investigate and situate correct drug delivery to a target lesion. Third, at the target lesion, the external magnetic field is turned off and the two axial magnetized soft-magnetic rings of the drug-delivery module are demagnetized. Fourth, when we apply a strong pulsating magnetic field in a radial direction, the drug-delivery module is opened by the repulsive force between the two radially magnetized soft-magnetic rings, and the encapsulated drug can be released. After the drug release, the drug-delivery module can be returned to its initial shape thanks to an integrated plastic hinge in the drug delivery module and the attracting force between two axially magnetized soft-magnetic rings. Finally, the active CE can continue to show its intrinsic diagnostic work. Consequently, we demonstrate the feasibility of the drug-delivery module which is integrated in ALICE.
AB - Nowadays, capsule endoscope (CE) technology is highly evaluated as a promising medical apparatus for minimally invasive diagnosis and therapy. Active locomotive capsule endoscopy (ALICE) using an electromagnetic actuation (EMA) system is one of the new state-of-the-art solutions that effectively increase the diagnostic ability of CE. Together with a locomotive CE, there are various requests for multifunctional modules that can deliver drugs or execute biopsy functions. This paper presents a drug delivery module for ALICE using EMA, where we adopt a soft magnet due to its special physical properties. The drug-delivery module consists of two ring-type soft magnets and a simple plastic hinge; it has a volume of 0.78 ml, which is approximately 26% the total volume of a conventional active CE. The drug-delivery module can be integrated with ALICE. First, the drug is encapsulated into the module by the attracting force between two axially magnetized soft-magnetic rings. Second, ALICE with the drug delivery module can be driven by a precisely controlled external magnetic field to investigate and situate correct drug delivery to a target lesion. Third, at the target lesion, the external magnetic field is turned off and the two axial magnetized soft-magnetic rings of the drug-delivery module are demagnetized. Fourth, when we apply a strong pulsating magnetic field in a radial direction, the drug-delivery module is opened by the repulsive force between the two radially magnetized soft-magnetic rings, and the encapsulated drug can be released. After the drug release, the drug-delivery module can be returned to its initial shape thanks to an integrated plastic hinge in the drug delivery module and the attracting force between two axially magnetized soft-magnetic rings. Finally, the active CE can continue to show its intrinsic diagnostic work. Consequently, we demonstrate the feasibility of the drug-delivery module which is integrated in ALICE.
KW - Capsule endoscope
KW - Drug delivery module
KW - Electromagnetic actuation system
KW - Soft magnet material
UR - http://www.scopus.com/inward/record.url?scp=84961575219&partnerID=8YFLogxK
U2 - 10.1016/j.sna.2016.03.020
DO - 10.1016/j.sna.2016.03.020
M3 - Article
AN - SCOPUS:84961575219
SN - 0924-4247
VL - 243
SP - 81
EP - 89
JO - Sensors and Actuators, A: Physical
JF - Sensors and Actuators, A: Physical
ER -