A sensory-motor neuron type mediates proprioceptive coordination of steering in C. elegans via two TRPC channels

Jihye Yeon, Jinmahn Kim, Do Young Kim, Hyunmin Kim, Jungha Kim, Eun Jo Du, Kyeong Jin Kang, Hyun Ho Lim, Daewon Moon, Kyuhyung Kim

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Animal locomotion is mediated by a sensory system referred to as proprioception. Defects in the proprioceptive coordination of locomotion result in uncontrolled and inefficient movements. However, the molecular mechanisms underlying proprioception are not fully understood. Here, we identify two transient receptor potential cation (TRPC) channels, trp-1 and trp-2, as necessary and sufficient for proprioceptive responses in C. elegans head steering locomotion. Both channels are expressed in the SMDD neurons, which are required and sufficient for head bending, and mediate coordinated head steering by sensing mechanical stretches due to the contraction of head muscle and orchestrating dorsal head muscle contractions. Moreover, the SMDD neurons play dual roles to sense muscle stretch as well as to control muscle contractions. These results demonstrate that distinct locomotion patterns require dynamic and homeostatic modulation of feedback signals between neurons and muscles.

Original languageEnglish
Article numbere2004929
JournalPLoS Biology
Volume16
Issue number6
DOIs
StatePublished - Jun 2018

Bibliographical note

Publisher Copyright:
© 2018 Yeon et al. http://creativecommons.org/licenses/by/4.0/

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