A pilot study of planar coil based magnetic stimulation using acute hippocampal slice in mice

H. J. Park; H. K. Kang; M. Wang; J. Jo; E. Chung; S. Kim

doi:10.1109/EMBC.2017.8037025

A pilot study of planar coil based magnetic stimulation using acute hippocampal slice in mice

H. J. Park, H. K. Kang, M. Wang, J. Jo, E. Chung, S. Kim

Department of Robotics and Mechatronics Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

4 Scopus citations

Abstract

Micromagnetic stimulation using small-sized implantable coils has recently been studied. The main advantage of this method is that it can provide sustainable stimulation performance even if a fibrotic encapsulation layer is formed around the implanted coil by inflammation response, because indirectly induced currents are used to induce neural responses. In previous research, we optimized the geometrical and control parameters used in implantable magnetic stimulation. Based on those results, we fabricated the planar coil and studied the LTP effect in the hippocampal slice by two different magnetic stimulation protocols using the quadripulse stimulation (QPS) pattern. We found that direct magnetic stimulation (DMS) induced insignificant LTP effect and priming magnetic stimulation (PMS) occluded LTP effect after tetanic stimulation, when QPS patterned magnetic stimulation with 1 A current pulse was applied to the planar coil.

Original language	English
Title of host publication	2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publication	Smarter Technology for a Healthier World, EMBC 2017 - Proceedings
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	1118-1121
Number of pages	4
ISBN (Electronic)	9781509028092
DOIs	https://doi.org/10.1109/EMBC.2017.8037025
State	Published - 13 Sep 2017
Event	39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017 - Jeju Island, Korea, Republic of Duration: 11 Jul 2017 → 15 Jul 2017

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)	1557-170X

Conference

Conference	39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017
Country/Territory	Korea, Republic of
City	Jeju Island
Period	11/07/17 → 15/07/17

Bibliographical note

Publisher Copyright:
© 2017 IEEE.

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10.1109/EMBC.2017.8037025

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Park, H. J., Kang, H. K., Wang, M., Jo, J., Chung, E., & Kim, S. (2017). A pilot study of planar coil based magnetic stimulation using acute hippocampal slice in mice. In 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings (pp. 1118-1121). Article 8037025 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2017.8037025

Park, H. J. ; Kang, H. K. ; Wang, M. et al. / A pilot study of planar coil based magnetic stimulation using acute hippocampal slice in mice. 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2017. pp. 1118-1121 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

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abstract = "Micromagnetic stimulation using small-sized implantable coils has recently been studied. The main advantage of this method is that it can provide sustainable stimulation performance even if a fibrotic encapsulation layer is formed around the implanted coil by inflammation response, because indirectly induced currents are used to induce neural responses. In previous research, we optimized the geometrical and control parameters used in implantable magnetic stimulation. Based on those results, we fabricated the planar coil and studied the LTP effect in the hippocampal slice by two different magnetic stimulation protocols using the quadripulse stimulation (QPS) pattern. We found that direct magnetic stimulation (DMS) induced insignificant LTP effect and priming magnetic stimulation (PMS) occluded LTP effect after tetanic stimulation, when QPS patterned magnetic stimulation with 1 A current pulse was applied to the planar coil.",

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Park, HJ, Kang, HK, Wang, M, Jo, J, Chung, E & Kim, S 2017, A pilot study of planar coil based magnetic stimulation using acute hippocampal slice in mice. in 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings., 8037025, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, Institute of Electrical and Electronics Engineers Inc., pp. 1118-1121, 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017, Jeju Island, Korea, Republic of, 11/07/17. https://doi.org/10.1109/EMBC.2017.8037025

A pilot study of planar coil based magnetic stimulation using acute hippocampal slice in mice. / Park, H. J.; Kang, H. K.; Wang, M. et al.
2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2017. p. 1118-1121 8037025 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AB - Micromagnetic stimulation using small-sized implantable coils has recently been studied. The main advantage of this method is that it can provide sustainable stimulation performance even if a fibrotic encapsulation layer is formed around the implanted coil by inflammation response, because indirectly induced currents are used to induce neural responses. In previous research, we optimized the geometrical and control parameters used in implantable magnetic stimulation. Based on those results, we fabricated the planar coil and studied the LTP effect in the hippocampal slice by two different magnetic stimulation protocols using the quadripulse stimulation (QPS) pattern. We found that direct magnetic stimulation (DMS) induced insignificant LTP effect and priming magnetic stimulation (PMS) occluded LTP effect after tetanic stimulation, when QPS patterned magnetic stimulation with 1 A current pulse was applied to the planar coil.

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Park HJ, Kang HK, Wang M, Jo J, Chung E, Kim S. A pilot study of planar coil based magnetic stimulation using acute hippocampal slice in mice. In 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc. 2017. p. 1118-1121. 8037025. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: 10.1109/EMBC.2017.8037025

A pilot study of planar coil based magnetic stimulation using acute hippocampal slice in mice

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