A microelectromechanical system artificial basilar membrane based on a piezoelectric cantilever array and its characterization using an animal model

Jongmoon Jang; Jangwoo Lee; Seongyong Woo; David J. Sly; Luke J. Campbell; Jin Ho Cho; Stephen J. O'Leary; Min Hyun Park; Sungmin Han; Ji Wong Choi; Jeong Hun Jang; Hongsoo Choi

doi:10.1038/srep12447

A microelectromechanical system artificial basilar membrane based on a piezoelectric cantilever array and its characterization using an animal model

Jongmoon Jang, Jangwoo Lee, Seongyong Woo, David J. Sly, Luke J. Campbell, Jin Ho Cho, Stephen J. O'Leary, Min Hyun Park, Sungmin Han, Ji Wong Choi, Jeong Hun Jang, Hongsoo Choi

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Abstract

We proposed a piezoelectric artificial basilar membrane (ABM) composed of a microelectromechanical system cantilever array. The ABM mimics the tonotopy of the cochlea: frequency selectivity and mechanoelectric transduction. The fabricated ABM exhibits a clear tonotopy in an audible frequency range (2.92-12.6 €‰kHz). Also, an animal model was used to verify the characteristics of the ABM as a front end for potential cochlear implant applications. For this, a signal processor was used to convert the piezoelectric output from the ABM to an electrical stimulus for auditory neurons. The electrical stimulus for auditory neurons was delivered through an implanted intra-cochlear electrode array. The amplitude of the electrical stimulus was modulated in the range of 0.15 to 3.5 €‰V with incoming sound pressure levels (SPL) of 70.1 to 94.8 €‰dB SPL. The electrical stimulus was used to elicit an electrically evoked auditory brainstem response (EABR) from deafened Guinea pigs. EABRs were successfully measured and their magnitude increased upon application of acoustic stimuli from 75 to 95 €‰dB SPL. The frequency selectivity of the ABM was estimated by measuring the magnitude of EABRs while applying sound pressure at the resonance and off-resonance frequencies of the corresponding cantilever of the selected channel. In this study, we demonstrated a novel piezoelectric ABM and verified its characteristics by measuring EABRs.

Original language	English
Article number	12447
Journal	Scientific Reports
Volume	5
DOIs	https://doi.org/10.1038/srep12447
State	Published - 31 Jul 2015

Bibliographical note

Funding Information:
We thank the Center for Core Research Facilities of DGIST for technical support for MEMS fabrication. The authors are also grateful to Dr. Won Joon Song (Hanbat National University) for help with the acoustic measurement and frequency analysis, Mr. Youngjun Kim (Microtech) for technical support with the signal processor and Han-Joon Kim (DGIST) for assistance with the design of the signal process. Part of the funding for this research was provided by a National Research Foundation of Korea grant funded by the Korean Government (2011-0013638, 2014R1A2A2A01006223, and 2013R1A2A1A09015677) and by DGIST MIREBraiN Project.

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Jang, J., Lee, J., Woo, S., Sly, D. J., Campbell, L. J., Cho, J. H., O'Leary, S. J., Park, M. H., Han, S., Choi, J. W., Hun Jang, J., & Choi, H. (2015). A microelectromechanical system artificial basilar membrane based on a piezoelectric cantilever array and its characterization using an animal model. Scientific Reports, 5, Article 12447. https://doi.org/10.1038/srep12447

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title = "A microelectromechanical system artificial basilar membrane based on a piezoelectric cantilever array and its characterization using an animal model",

abstract = "We proposed a piezoelectric artificial basilar membrane (ABM) composed of a microelectromechanical system cantilever array. The ABM mimics the tonotopy of the cochlea: frequency selectivity and mechanoelectric transduction. The fabricated ABM exhibits a clear tonotopy in an audible frequency range (2.92-12.6 €‰kHz). Also, an animal model was used to verify the characteristics of the ABM as a front end for potential cochlear implant applications. For this, a signal processor was used to convert the piezoelectric output from the ABM to an electrical stimulus for auditory neurons. The electrical stimulus for auditory neurons was delivered through an implanted intra-cochlear electrode array. The amplitude of the electrical stimulus was modulated in the range of 0.15 to 3.5 €‰V with incoming sound pressure levels (SPL) of 70.1 to 94.8 €‰dB SPL. The electrical stimulus was used to elicit an electrically evoked auditory brainstem response (EABR) from deafened Guinea pigs. EABRs were successfully measured and their magnitude increased upon application of acoustic stimuli from 75 to 95 €‰dB SPL. The frequency selectivity of the ABM was estimated by measuring the magnitude of EABRs while applying sound pressure at the resonance and off-resonance frequencies of the corresponding cantilever of the selected channel. In this study, we demonstrated a novel piezoelectric ABM and verified its characteristics by measuring EABRs.",

author = "Jongmoon Jang and Jangwoo Lee and Seongyong Woo and Sly, {David J.} and Campbell, {Luke J.} and Cho, {Jin Ho} and O'Leary, {Stephen J.} and Park, {Min Hyun} and Sungmin Han and Choi, {Ji Wong} and {Hun Jang}, Jeong and Hongsoo Choi",

note = "Funding Information: We thank the Center for Core Research Facilities of DGIST for technical support for MEMS fabrication. The authors are also grateful to Dr. Won Joon Song (Hanbat National University) for help with the acoustic measurement and frequency analysis, Mr. Youngjun Kim (Microtech) for technical support with the signal processor and Han-Joon Kim (DGIST) for assistance with the design of the signal process. Part of the funding for this research was provided by a National Research Foundation of Korea grant funded by the Korean Government (2011-0013638, 2014R1A2A2A01006223, and 2013R1A2A1A09015677) and by DGIST MIREBraiN Project.",

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doi = "10.1038/srep12447",

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T1 - A microelectromechanical system artificial basilar membrane based on a piezoelectric cantilever array and its characterization using an animal model

AU - Jang, Jongmoon

AU - Lee, Jangwoo

AU - Woo, Seongyong

AU - Sly, David J.

AU - Campbell, Luke J.

AU - Cho, Jin Ho

AU - O'Leary, Stephen J.

AU - Park, Min Hyun

AU - Han, Sungmin

AU - Choi, Ji Wong

AU - Hun Jang, Jeong

AU - Choi, Hongsoo

N1 - Funding Information: We thank the Center for Core Research Facilities of DGIST for technical support for MEMS fabrication. The authors are also grateful to Dr. Won Joon Song (Hanbat National University) for help with the acoustic measurement and frequency analysis, Mr. Youngjun Kim (Microtech) for technical support with the signal processor and Han-Joon Kim (DGIST) for assistance with the design of the signal process. Part of the funding for this research was provided by a National Research Foundation of Korea grant funded by the Korean Government (2011-0013638, 2014R1A2A2A01006223, and 2013R1A2A1A09015677) and by DGIST MIREBraiN Project.

PY - 2015/7/31

Y1 - 2015/7/31

N2 - We proposed a piezoelectric artificial basilar membrane (ABM) composed of a microelectromechanical system cantilever array. The ABM mimics the tonotopy of the cochlea: frequency selectivity and mechanoelectric transduction. The fabricated ABM exhibits a clear tonotopy in an audible frequency range (2.92-12.6 €‰kHz). Also, an animal model was used to verify the characteristics of the ABM as a front end for potential cochlear implant applications. For this, a signal processor was used to convert the piezoelectric output from the ABM to an electrical stimulus for auditory neurons. The electrical stimulus for auditory neurons was delivered through an implanted intra-cochlear electrode array. The amplitude of the electrical stimulus was modulated in the range of 0.15 to 3.5 €‰V with incoming sound pressure levels (SPL) of 70.1 to 94.8 €‰dB SPL. The electrical stimulus was used to elicit an electrically evoked auditory brainstem response (EABR) from deafened Guinea pigs. EABRs were successfully measured and their magnitude increased upon application of acoustic stimuli from 75 to 95 €‰dB SPL. The frequency selectivity of the ABM was estimated by measuring the magnitude of EABRs while applying sound pressure at the resonance and off-resonance frequencies of the corresponding cantilever of the selected channel. In this study, we demonstrated a novel piezoelectric ABM and verified its characteristics by measuring EABRs.

AB - We proposed a piezoelectric artificial basilar membrane (ABM) composed of a microelectromechanical system cantilever array. The ABM mimics the tonotopy of the cochlea: frequency selectivity and mechanoelectric transduction. The fabricated ABM exhibits a clear tonotopy in an audible frequency range (2.92-12.6 €‰kHz). Also, an animal model was used to verify the characteristics of the ABM as a front end for potential cochlear implant applications. For this, a signal processor was used to convert the piezoelectric output from the ABM to an electrical stimulus for auditory neurons. The electrical stimulus for auditory neurons was delivered through an implanted intra-cochlear electrode array. The amplitude of the electrical stimulus was modulated in the range of 0.15 to 3.5 €‰V with incoming sound pressure levels (SPL) of 70.1 to 94.8 €‰dB SPL. The electrical stimulus was used to elicit an electrically evoked auditory brainstem response (EABR) from deafened Guinea pigs. EABRs were successfully measured and their magnitude increased upon application of acoustic stimuli from 75 to 95 €‰dB SPL. The frequency selectivity of the ABM was estimated by measuring the magnitude of EABRs while applying sound pressure at the resonance and off-resonance frequencies of the corresponding cantilever of the selected channel. In this study, we demonstrated a novel piezoelectric ABM and verified its characteristics by measuring EABRs.

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DO - 10.1038/srep12447

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SN - 2045-2322

VL - 5

JO - Scientific Reports

JF - Scientific Reports

M1 - 12447

ER -

A microelectromechanical system artificial basilar membrane based on a piezoelectric cantilever array and its characterization using an animal model

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