Abstract
In this study, a simple and robust microfluidic platform is presented, which can interconnect and culture multiple microtissues (MTs) as 96-well format-based platform. Human colon cancer (HCT116) MTs were cultured over 4 days and exposed to various concentrations of endoxifen. Drug resistance was observed when HCT116 MTs were cultured under perfusion conditions. It addresses the feasibility of our microfluidic platform for more complex and comprehensive pharmacokinetic study in an in vivo-like in vitro physiological environment.
| Original language | English |
|---|---|
| Title of host publication | MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 1689-1690 |
| Number of pages | 2 |
| ISBN (Electronic) | 9781733419031 |
| State | Published - 2021 |
| Event | 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 - Palm Springs, Virtual, United States Duration: 10 Oct 2021 → 14 Oct 2021 |
Publication series
| Name | MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
|---|
Conference
| Conference | 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 |
|---|---|
| Country/Territory | United States |
| City | Palm Springs, Virtual |
| Period | 10/10/21 → 14/10/21 |
Bibliographical note
Publisher Copyright:© 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.
Keywords
- 3D cell culture
- High-throughput drug screening
- Microfluidics
- Microtissue
