Research output per year
Research output per year
Personal profile
Education
- 2004-2010 Ph.D., Institute for Cellular and Molecular Biology, University of Texas at Austin
- 1997-1999 M.S., Department of Chemistry, Seoul National University
- 1993-1997 B.S., Department of Chemistry, Seoul National Universtiy
- 1997-1999 M.S., Department of Chemistry, Seoul National University
- 1993-1997 B.S., Department of Chemistry, Seoul National Universtiy
Professional Experience
- 2019-present Associate Professor, Department of New Biology, DGIST
- 2016-2019 Assistant Professor, Department of New Biology, DGIST
- 2013-2016 Senior Staff Researcher, Well-Aging Research Center, Samsung Advanced Institute of Technology
- 2010-2013 Postdoctoral Fellow, NIDDK, NIH
- 2016-2019 Assistant Professor, Department of New Biology, DGIST
- 2013-2016 Senior Staff Researcher, Well-Aging Research Center, Samsung Advanced Institute of Technology
- 2010-2013 Postdoctoral Fellow, NIDDK, NIH
Research Interests
- Mechanism of cellular senescence and reversing aging
- Structural and functional studies of age-related proteins
- Molecular mechanism of eukaryotic DNA polymerases
- Structural and functional studies of age-related proteins
- Molecular mechanism of eukaryotic DNA polymerases
Major Research Achievements
- Cho et al., Nintedanib induces senolytic effect via STAT3 inhibition. Cell Death Dis. (2022) 13(9):760.
- Park et al., Disruption of nucleocytoplasmic trafficking as a cellular senescence driver. Exp Mol Med. (2021), 53(6):1092-1108.
- Kang et al., Chemical screening identifies ATM as a target for alleviating senescence. Nature Chem Biol (2017), 13(6):616-623
- Lee et al., How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis. Nature Struct Mol Biol, (2015) 22(4):298-303
- Lee et al., Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations. Cell (2009) 139:312-324
- Park et al., Disruption of nucleocytoplasmic trafficking as a cellular senescence driver. Exp Mol Med. (2021), 53(6):1092-1108.
- Kang et al., Chemical screening identifies ATM as a target for alleviating senescence. Nature Chem Biol (2017), 13(6):616-623
- Lee et al., How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis. Nature Struct Mol Biol, (2015) 22(4):298-303
- Lee et al., Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations. Cell (2009) 139:312-324
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Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Animal-free scaffold from brown algae provides a three-dimensional cell growth and differentiation environment for steak-like cultivated meat
Lee, H., Kim, D., Choi, K. H., Lee, S., Jo, M., Chun, S. Y., Son, Y., Lee, J. H., Kim, K., Lee, T. B., Keum, J., Yoon, M., Cha, H. J., Rho, S., Cho, S. C. & Lee, Y. S., Jul 2024, In: Food Hydrocolloids. 152, 109944.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Brief guide to senescence assays using cultured mammalian cells
Kang, E., Kang, C., Lee, Y. S. & Lee, S. J. V., Sep 2024, In: Molecules and Cells. 47, 9, 100102.Research output: Contribution to journal › Letter › peer-review
Open Access3 Scopus citations -
From Homogeneity to Turing Pattern: Kinetically Controlled Self-Organization of Transmembrane Protein
Lee, W. J., Kim, S. J., Ahn, Y., Park, J., Jin, S., Jang, J., Jeong, J., Park, M., Lee, Y. S., Lee, J. & Seo, D., 14 Feb 2024, In: Nano Letters. 24, 6, p. 1882-1890 9 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
The ICL1 and MLS1 Genes, Integral to the Glyoxylate Cycle, are Essential and Specific for Caloric Restriction-Mediated Extension of Lifespan in Budding Yeast
Kwon, Y. Y., Lee, H. J., Lee, M. J., Lee, Y. S. & Lee, C. K., Sep 2024, In: Advanced Biology. 8, 9, 2400083.Research output: Contribution to journal › Article › peer-review
Open Access -
Analysis of Phase Heterogeneity in Lipid Membranes Using Single-Molecule Tracking in Live Cells
Park, J., Ahn, Y., Lee, W. J., Jin, S., Jeong, S., Kim, J., Lee, Y. S., Lee, J. C. & Seo, D., 31 Oct 2023, In: Analytical Chemistry. 95, 43, p. 15924-15932 9 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations