Research output per year
Research output per year
Personal profile
Education
- 2011 Ph.D., Seoul National University, Seoul, South Korea
- 2008 M.S., Seoul National University, Seoul, South Korea
- 2006 B.S., Yonsei Universtiy, Seoul, South Korea
- 2008 M.S., Seoul National University, Seoul, South Korea
- 2006 B.S., Yonsei Universtiy, Seoul, South Korea
Professional Experience
- 2011. 5. - 2013. 12. HHMI Postdoctoral Fellow, The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, MIT, Cambridge, USA.
- 2014. 1. - 2015. 4. Postdoctoral Associate, The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, MIT, Cambridge, USA.
- 2015. 5. - 2017. 8. Research Scientist, The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, MIT, Cambridge, USA.
- 2017. 9. - present Assistant, Associate Professor, Department of Brain Sciences, DGIST, Daegu, South Korea
- 2014. 1. - 2015. 4. Postdoctoral Associate, The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, MIT, Cambridge, USA.
- 2015. 5. - 2017. 8. Research Scientist, The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, MIT, Cambridge, USA.
- 2017. 9. - present Assistant, Associate Professor, Department of Brain Sciences, DGIST, Daegu, South Korea
Research Interests
- Searching key factors and the underlying mechanisms mediating or accelerating age-associated cellular dysfunction and cognitive impairment.
- Studying the pathological role of genetic and environmental risk factors associated with age-associated neurodegenerative diseases including Alzheimer’s disease.
- Elucidating underlying mechanisms of neurodegenerative disease-causing risk factors to develop novel therapeutics for preventing or ameliorating pathology.
- Utilizing patients or healthy individuals-derived induced pluripotent stem cells (iPSCs) and the CRISPR/Cas9 genome-editing tool to establish human model systems for studying aging brain and neurodegenerative diseases.
- Studying the pathological role of genetic and environmental risk factors associated with age-associated neurodegenerative diseases including Alzheimer’s disease.
- Elucidating underlying mechanisms of neurodegenerative disease-causing risk factors to develop novel therapeutics for preventing or ameliorating pathology.
- Utilizing patients or healthy individuals-derived induced pluripotent stem cells (iPSCs) and the CRISPR/Cas9 genome-editing tool to establish human model systems for studying aging brain and neurodegenerative diseases.
Major Research Achievements
- Pao PC, Seo J, Lee A, Kritskiy O, Patnaik D, Penney J, Raju RM, Geigenmuller U, Silva MC, Lucente DE, Gusella JF, Dickerson BC, Loon A, Yu MX, Bula M, Yu M, Haggarty SJ, Tsai LH (2023) A novel Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes. Proc Natl Acad Sci U S A 120(16) e2217864120
- Lee SI, Jeong W, Lim H, Cho S, Lee H, Jang Y, Cho J, Bae S, Lin YT, Tsai LH, Moon DW, Seo J (2021) ApoE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid rafts expansion and Aβ generation. Stem Cell Reports 16(9):2128-2137
- Lin YT*, Seo J*, Gao F, Feldman HM, Wen HL, Penney J, Cam HP, Gjoneska E, Raja WK, Cheng J, Rueda R, Kritskiy O, Abdurrob F, Peng Z, Milo B, Yu CJ, Elmsaouri S, Dey D, Ko T, Yankner BA, Tsai LH (2018) APOE4 causes widespread molecular and cellular alterations associated with Alzheimer’s disease phenotypes across human iPSC-derived brain cell types. Neuron 98(6):1141-1154.
- Seo J, Giusti-Rodriguez P, Zhou Y, Rudenko A, Cho S, Ota KT, Park C, Patzke H, Madbhushi R, Pan L, Mungenast AE, Guan JS, Delalle I, Tsai LH. (2014) Activity-dependent p25 generation regulates synaptic plasticity and Aβ-induced cognitive impairment. Cell 157(2):486-98.
- 2018. Chung-am Science Fellowship, POSCO TJ Park Foundation
- Lee SI, Jeong W, Lim H, Cho S, Lee H, Jang Y, Cho J, Bae S, Lin YT, Tsai LH, Moon DW, Seo J (2021) ApoE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid rafts expansion and Aβ generation. Stem Cell Reports 16(9):2128-2137
- Lin YT*, Seo J*, Gao F, Feldman HM, Wen HL, Penney J, Cam HP, Gjoneska E, Raja WK, Cheng J, Rueda R, Kritskiy O, Abdurrob F, Peng Z, Milo B, Yu CJ, Elmsaouri S, Dey D, Ko T, Yankner BA, Tsai LH (2018) APOE4 causes widespread molecular and cellular alterations associated with Alzheimer’s disease phenotypes across human iPSC-derived brain cell types. Neuron 98(6):1141-1154.
- Seo J, Giusti-Rodriguez P, Zhou Y, Rudenko A, Cho S, Ota KT, Park C, Patzke H, Madbhushi R, Pan L, Mungenast AE, Guan JS, Delalle I, Tsai LH. (2014) Activity-dependent p25 generation regulates synaptic plasticity and Aβ-induced cognitive impairment. Cell 157(2):486-98.
- 2018. Chung-am Science Fellowship, POSCO TJ Park Foundation
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Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Correction to: Gamma frequency entrainment attenuates amyloid load and modifies microglia (Nature, (2016), 540, 7632, (230-235), 10.1038/nature20587)
Iaccarino, H. F., Singer, A. C., Martorell, A. J., Rudenko, A., Gao, F., Gillingham, T. Z., Mathys, H., Seo, J., Kritskiy, O., Abdurrob, F., Adaikkan, C., Canter, R. G., Rueda, R., Brown, E. N., Boyden, E. S. & Tsai, L. H., 12 Dec 2024, In: Nature. 636, 8042, p. E2Research output: Contribution to journal › Comment/debate
Open Access -
Correction to: ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells (Nature Communications, (2023), 14, 1, (8463), 10.1038/s41467-023-44319-3)
Lee, J., Lee, H., Lee, H., Shin, M., Shin, M. G., Seo, J., Lee, E. J., Park, S. A. & Park, S., Dec 2024, In: Nature Communications. 15, 1, 3062.Research output: Contribution to journal › Comment/debate
Open Access -
A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes
Pao, P. C., Seo, J., Lee, A., Kritskiy, O., Patnaik, D., Penney, J., Raju, R. M., Geigenmuller, U., Silva, M. C., Lucente, D. E., Gusella, J. F., Dickerson, B. C., Loon, A., Yu, M. X., Bula, M., Yu, M., Haggarty, S. J. & Tsai, L. H., 18 Apr 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 16, e2217864120.Research output: Contribution to journal › Article › peer-review
Open Access -
ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells
Lee, J., Lee, H., Lee, H., Shin, M., Shin, M. G., Seo, J., Lee, E. J., Park, S. A. & Park, S., Dec 2023, In: Nature Communications. 14, 1, 8463.Research output: Contribution to journal › Article › peer-review
Open Access -
ApoE4-dependent lysosomal cholesterol accumulation impairs mitochondrial homeostasis and oxidative phosphorylation in human astrocytes
Lee, H., Cho, S., Kim, M. J., Park, Y. J., Cho, E., Jo, Y. S., Kim, Y. S., Lee, J. Y., Thoudam, T., Woo, S. H., Lee, S. I., Jeon, J., Lee, Y. S., Suh, B. C., Yoon, J. H., Go, Y., Lee, I. K. & Seo, J., 31 Oct 2023, In: Cell Reports. 42, 10, 113183.Research output: Contribution to journal › Article › peer-review
Open Access