Research output per year
Research output per year
Personal profile
Education
- 2004 Ph.D., University of Texas Southwestern Medical Center
- 1998 M.S., Seoul National University
- 1996 B.S., Seoul National University
- 1998 M.S., Seoul National University
- 1996 B.S., Seoul National University
Professional Experience
- 2006-2007 Postdoctoral fellow, MIT
- 2007-2016 Postdoctoral fellow, Harvard Medical School
- 2016-2021 Assistant Professor, Department of New Biology, DGIST
- 2021-present Associate Professor, Department of New Biology, DGIST
- 2018-present Scientific Advisory Board, Ubix Therapeutics
- 2007-2016 Postdoctoral fellow, Harvard Medical School
- 2016-2021 Assistant Professor, Department of New Biology, DGIST
- 2021-present Associate Professor, Department of New Biology, DGIST
- 2018-present Scientific Advisory Board, Ubix Therapeutics
Research Interests
- Deubiquitinating enzymes (DUBs) in human diseases and aging
- Chemo-genomic screening of DUBs and DUB inhibitors
- Targeted protein degradation (TPD) and induced protein degradation
- Developing proteolytic strategies for targeting the “undruggables”
- Elucidating dynamic nature of DUBs and proteasome for proteolysis
- Chemo-genomic screening of DUBs and DUB inhibitors
- Targeted protein degradation (TPD) and induced protein degradation
- Developing proteolytic strategies for targeting the “undruggables”
- Elucidating dynamic nature of DUBs and proteasome for proteolysis
Major Research Achievements
- Allosteric control of Ubp6 and the proteasome via a bidirectional switch, Nat Commun (2022)
- Excellence in Teaching Award (2020), DGIST
- USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites, Nature (2016)
- Substrate degradation by the proteasome: a single-molecule kinetic analysis, Science (2015)
- Alfred Gilman Award (2004), UT Southwestern Medical Center
- Excellence in Teaching Award (2020), DGIST
- USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites, Nature (2016)
- Substrate degradation by the proteasome: a single-molecule kinetic analysis, Science (2015)
- Alfred Gilman Award (2004), UT Southwestern Medical Center
URL
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Collaborations and top research areas from the last five years
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Biallelic USP14 variants cause a syndromic neurodevelopmental disorder
Ebstein, F., Latypova, X., Sharon Hung, K. Y., Prado, M. A., Lee, B. H., Möller, S., Wendlandt, M., Zieba, B. A., Florenceau, L., Vignard, V., Poirier, L., Toutain, B., Moroni, I., Dubucs, C., Chassaing, N., Horvath, J., Prokisch, H., Küry, S., Bézieau, S. & Paulo, J. A. & 4 others, , Jun 2024, In: Genetics in Medicine. 26, 6, 101120.Research output: Contribution to journal › Article › peer-review
Open Access -
Pharmacological inhibition of USP14 delays proteostasis-associated aging in a proteasome-dependent but foxo-independent manner
Lim, J. J., Noh, S., Kang, W., Hyun, B., Lee, B. H. & Hyun, S., 2024, In: Autophagy. 20, 12, p. 2752-2768 17 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Structural Dynamics Analysis of USP14 Activation by AKT-Mediated Phosphorylation
Dash, R., Tran, N. N., Lee, S. B. & Lee, B. H., Jun 2024, In: Cells. 13, 11, 955.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Orally bioavailable BTK PROTAC active against wild-type and C481 mutant BTKs in human lymphoma CDX mouse models
Lim, Y. S., Yoo, S. M., Patil, V., Kim, H. W., Kim, H. H., Suh, B., Park, J. Y., Jeong, N. R., Park, C. H., Ryu, J. H., Lee, B. H., Kim, P. & Lee, S. H., 10 Jan 2023, In: Blood Advances. 7, 1, p. 92-105 14 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Allosteric control of Ubp6 and the proteasome via a bidirectional switch
Hung, K. Y. S., Klumpe, S., Eisele, M. R., Elsasser, S., Tian, G., Sun, S., Moroco, J. A., Cheng, T. C., Joshi, T., Seibel, T., Van Dalen, D., Feng, X. H., Lu, Y., Ovaa, H., Engen, J. R., Lee, B. H., Rudack, T., Sakata, E. & Finley, D., Dec 2022, In: Nature Communications. 13, 1, 838.Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations